The Convento de San Francisco was commissioned in the 15th century and built on the site of a 12th century Nasrid palace. It is today the site of a national parador (hotel) called the Parador de San Francisco.
Source:
The Alhambra and the Generalife: Official Guide. Madrid: Patronato de la Alhambra y Generalife and Tf Editores, 2010.